Gut dysbiosis and the clinical spectrum in anti-Ro positive mothers of children with neonatal lupus.
Gut Microbes
; 14(1): 2081474, 2022.
Article
em En
| MEDLINE
| ID: mdl-35704681
ABSTRACT
Anti-SSA/Ro antibodies, while strongly linked to fetal cardiac injury and neonatal rash, can associate with a spectrum of disease in the mother, ranging from completely asymptomatic to overt Systemic Lupus Erythematosus (SLE) or Sjögren's Syndrome (SS). This study was initiated to test the hypothesis that the microbiome, influenced in part by genetics, contributes to disease state. The stool microbiome of healthy controls (HC) was compared to that of anti-SSA/Ro positive women whose children had neonatal lupus. At the time of sampling, these women were either asymptomatic (Asym), had minor rheumatic symptoms or signs considered as an undifferentiated autoimmune syndrome (UAS), or were diagnosed with SLE or SS. Differences in microbial relative abundances among these three groups were tested assuming an ordering in clinical severity (HCPalavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Sjogren
/
Microbioma Gastrointestinal
/
Lúpus Eritematoso Sistêmico
Tipo de estudo:
Diagnostic_studies
Limite:
Child
/
Female
/
Humans
/
Newborn
Idioma:
En
Revista:
Gut Microbes
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos