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The role of aquaporin 4 in brain tumors: implications for pathophysiology, diagnosis and therapy.
Behnam, Mohammad; Motamedzadeh, Alireza; Aalinezhad, Marzieh; Dadgostar, Ehsan; Rashidi Noshabad, Fatemeh Zahra; Pourfridoni, Mohammad; Raei, Maedeh; Mirzaei, Hamed; Aschner, Michael; Tamtaji, Omid Reza.
Afiliação
  • Behnam M; Student Research Committee, Kashan University of Medical Sciences, Kashan, I.R. of Iran.
  • Motamedzadeh A; Department of Internal Medicine, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, I.R. of Iran.
  • Aalinezhad M; Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. of Iran.
  • Dadgostar E; Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, I.R. of Iran.
  • Rashidi Noshabad FZ; Student Research Committee, Isfahan University of Medical Sciences, Isfahan, I.R. of Iran.
  • Pourfridoni M; Student Research Committee, Kashan University of Medical Sciences, Kashan, I.R. of Iran.
  • Raei M; Student Research Committee, Jiroft University of Medical Sciences, Jiroft, I.R. of Iran.
  • Mirzaei H; Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, I.R. of Iran.
  • Aschner M; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. of Iran. h.mirzaei2002@gmail.com.
  • Tamtaji OR; Department of Molecular Pharmacology, Albert Einstein College of Medicine, 10461, Bronx, NY, USA.
Mol Biol Rep ; 49(11): 10609-10615, 2022 Nov.
Article em En | MEDLINE | ID: mdl-35715607
Primary brain tumors are a heterogeneous group of tumors that arise from cells intrinsic to the central nervous system (CNS). Aquaporin-4 (AQP4) has been implicated in the pathogenesis of brain tumors. Previous reports have documented a relationship between AQP4 and several molecular pathways associated with the etiology of brain tumors, such as apoptosis, invasion and cell migration. AQP4 affects apoptosis via cytochrome C, Bad and Bcl-2, as well as invasion and migration via IDO1/TDO-Kyn-AhR axis, lncRNA LINC00461, miR-216a, miRNA-320a and MMPs. In addition, inhibition of AQP4 mitigates the progression of brain tumors. This review summarizes current knowledge and evidence regarding the relationship between AQP4 and brain tumors, and the mechanisms involved.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Aquaporina 4 / Glioma Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Mol Biol Rep Ano de publicação: 2022 Tipo de documento: Article País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Aquaporina 4 / Glioma Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Mol Biol Rep Ano de publicação: 2022 Tipo de documento: Article País de publicação: Holanda