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T Cell Senescence by Extensive Phenotyping: An Emerging Feature of COVID-19 Severity.
Zuin, Jenny; Fogar, Paola; Musso, Giulia; Padoan, Andrea; Piva, Elisa; Pelloso, Michela; Tosato, Francesca; Cattelan, Annamaria; Basso, Daniela; Plebani, Mario.
Afiliação
  • Zuin J; Department of Laboratory Medicine, Padova University-Hospital, Padova, Italy.
  • Fogar P; Department of Laboratory Medicine, Padova University-Hospital, Padova, Italy.
  • Musso G; Department of Laboratory Medicine, Padova University-Hospital, Padova, Italy.
  • Padoan A; Department of Medicine-DIMED, University of Padova, Padova, Italy.
  • Piva E; Department of Laboratory Medicine, Padova University-Hospital, Padova, Italy.
  • Pelloso M; Department of Medicine-DIMED, University of Padova, Padova, Italy.
  • Tosato F; Department of Laboratory Medicine, Padova University-Hospital, Padova, Italy.
  • Cattelan A; Department of Laboratory Medicine, Padova University-Hospital, Padova, Italy.
  • Basso D; Department of Laboratory Medicine, Padova University-Hospital, Padova, Italy.
  • Plebani M; Unit of Infectious and Tropical Diseases, Padova University-Hospital, Padova, Italy.
Lab Med ; 53(6): 609-613, 2022 Nov 03.
Article em En | MEDLINE | ID: mdl-35716073
ABSTRACT

OBJECTIVE:

To identify the potential prognostic value of lymphocyte subsets in COVID-19 patients, where lymphopenia is a common finding.

METHODS:

In 353 COVID-19 inpatients and 40 controls T cell subsets with markers of senescence and exhaustion were studied by flow cytometry.

RESULTS:

In severe illness, total lymphocytes B, NK, and all T subsets were dampened. Senescent CD4+, but mainly CD8+ T cells, increased in patients with respect to controls. The most significant index predicting fatal outcome was neutrophils/CD3+ T ratio.

CONCLUSION:

In conclusion, an altered T cell pattern underlies COVID-19 severity and is involved in predicting the outcome.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Lab Med Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Lab Med Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália