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Impact of stereotactic body radiotherapy vs palliative radiotherapy on oncologic outcomes of patients with metastatic kidney cancer concomitantly treated with immune checkpoint inhibitors: a preliminary, multicentre experience.
Francolini, Giulio; Campi, Riccardo; Di Cataldo, Vanessa; Detti, Beatrice; Loi, Mauro; Triggiani, Luca; La Mattina, Salvatore; Borghetti, Paolo; Magrini, Stefano Maria; Nicosia, Luca; Alongi, Filippo; Ghirardelli, Paolo; Vavassori, Vittorio; Allegra, Andrea Gaetano; Aquilano, Michele; Scoccimarro, Erika; Peruzzi, Anna; Pastina, Pierpaolo; Visani, Luca; Desideri, Isacco; Serni, Sergio; Meattini, Icro; Livi, Lorenzo.
Afiliação
  • Francolini G; Radiotherapy Unit, Azienda Ospedaliera Universitaria Careggi, Florence, Italy.
  • Campi R; Unit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy.
  • Di Cataldo V; Radiotherapy Department, Istituto Fiorentino di Cura e Assistenza, Florence, Italy.
  • Detti B; Radiotherapy Unit, Azienda Ospedaliera Universitaria Careggi, Florence, Italy. beatrice.detti@aouc.unifi.it.
  • Loi M; Radiotherapy Unit, Azienda Ospedaliera Universitaria Careggi, Florence, Italy.
  • Triggiani L; Department of Radiation Oncology, University and Spedali Civili Hospital, Brescia, Italy.
  • La Mattina S; Department of Radiation Oncology, University and Spedali Civili Hospital, Brescia, Italy.
  • Borghetti P; Department of Radiation Oncology, University and Spedali Civili Hospital, Brescia, Italy.
  • Magrini SM; Department of Radiation Oncology, University and Spedali Civili Hospital, Brescia, Italy.
  • Nicosia L; Radiation Oncology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy.
  • Alongi F; Radiation Oncology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy.
  • Ghirardelli P; Department of Radiotherapy, Cliniche Humanitas Gavazzeni, Bergamo, Italy.
  • Vavassori V; Department of Radiotherapy, Cliniche Humanitas Gavazzeni, Bergamo, Italy.
  • Allegra AG; Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
  • Aquilano M; Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
  • Scoccimarro E; Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
  • Peruzzi A; Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
  • Pastina P; Section of Radiation Oncology, Medical School, University of Siena, Siena, Italy.
  • Visani L; Radiotherapy Department, Istituto Fiorentino di Cura e Assistenza, Florence, Italy.
  • Desideri I; Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
  • Serni S; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Meattini I; Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
  • Livi L; Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
Clin Transl Oncol ; 24(10): 2039-2043, 2022 Oct.
Article em En | MEDLINE | ID: mdl-35739349
ABSTRACT

PURPOSE:

To explore the benefit yielded by radiotherapy (RT), we report a series of metastatic renal cell carcinoma (RCC) patients treated with concomitant RT plus Nivolumab. METHODS/PATIENTS Patients undergoing Nivolumab treatment plus concomitant RT (ablative or palliative) were included. RT was defined Ablative if >5 Gy/fraction were delivered.

RESULTS:

Ablative RT intent was the only independent predictor of both progression free and overall survival (HR 3.51, 95% CI 1.6-7.5, p = 0.0012 and HR 2.8, 95% CI 0.99-8.07, p = 0.05, respectively).

CONCLUSION:

Ablative RT may improve oncologic outcomes in selected patients with metastatic RCC treated with Nivolumab as compared to palliative RT.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Renais / Radiocirurgia / Neoplasias Renais Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Renais / Radiocirurgia / Neoplasias Renais Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália