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Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on the Hippocampus Proteome in a Porcine Model.
Yeste, Natalia; Pérez-Valle, Jorge; Vázquez-Gómez, Marta; García-Contreras, Consolación; González-Bulnes, Antonio; Bassols, Anna.
Afiliação
  • Yeste N; Departament de Bioquímica i Biologia Molecular, Facultat de Veterinària, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193 Barcelona, Spain.
  • Pérez-Valle J; Departament de Bioquímica i Biologia Molecular, Facultat de Veterinària, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193 Barcelona, Spain.
  • Vázquez-Gómez M; Faculty of Veterinary Sciences, UCM, Ciudad Universitaria s/n, 28040 Madrid, Spain.
  • García-Contreras C; Nutrition et Obesités: Approaches Systèmiques, NutriOmique, Sorbonne Université, INSERM, 75013 Paris, France.
  • González-Bulnes A; Department of Nutrition and Sustainable Animal Production, Estacion Experimental del Zaidin, CSIC, 18008 Granada, Spain.
  • Bassols A; Comparative Physiology Group, INIA, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain.
Antioxidants (Basel) ; 11(6)2022 Jun 09.
Article em En | MEDLINE | ID: mdl-35740029
Supplementation of a mother's diet with antioxidants such as hydroxytyrosol (HTX) has been proposed to ameliorate the adverse phenotypes of foetuses affected by intrauterine growth restriction (IUGR). Our previous studies showed, in a porcine model of IUGR, an effect of maternal HTX supplementation on the neurotransmitter profile of several brain areas and the morphology of the hippocampus in 100 days old foetuses. The present study analyzed the impact of maternal HTX supplementation on the hippocampus proteome at this foetal age by TMT10plex labelling. Eleven differentially abundant proteins were identified by comparing both conditions, and eight of them downregulated and three upregulated in the HTX-treated group. The downregulated proteins were mainly involved in protein synthesis and RNA metabolism and may explain the differences in neuron differentiation in the HTX-treated group. The upregulated proteins were related to cell detoxification and could represent a potential mechanism to explain the neuroprotective effect of HTX.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Antioxidants (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Espanha País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Antioxidants (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Espanha País de publicação: Suíça