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Gadolinium in Medical Imaging-Usefulness, Toxic Reactions and Possible Countermeasures-A Review.
Blomqvist, Lennart; Nordberg, Gunnar F; Nurchi, Valeria M; Aaseth, Jan O.
Afiliação
  • Blomqvist L; Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden.
  • Nordberg GF; Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, SE-17176 Stockholm, Sweden.
  • Nurchi VM; Division of Sustainable Health, Department of Public Health and Clinical Medicine, Umeå University, SE-90187 Umeå, Sweden.
  • Aaseth JO; Department of Life and Environmental Sciences, University of Cagliari, 09042 Cagliari, Italy.
Biomolecules ; 12(6)2022 05 24.
Article em En | MEDLINE | ID: mdl-35740867
Gadolinium (Gd) is one of the rare-earth elements. The properties of its trivalent cation (Gd3+) make it suitable to serve as the central ion in chelates administered intravenously to patients as a contrast agent in magnetic resonance imaging. Such Gd-chelates have been used for more than thirty years. During the past decades, knowledge has increased about potential harmful effects of Gd-chelates in patients with severe renal dysfunction. In such patients, there is a risk for a potentially disabling and lethal disease, nephrogenic systemic fibrosis. Restricting the use of Gd-chelates in persons with severely impaired renal function has decreased the occurrence of this toxic effect in the last decade. There has also been an increasing awareness of Gd-retention in the body, even in patients without renal dysfunction. The cumulative number of doses given, and the chemical structure of the chelate given, are factors of importance for retention in tissues. This review describes the chemical properties of Gd and its medically used chelates, as well as its toxicity and potential side effects related to injection of Gd-chelates.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gadolínio / Nefropatias Limite: Humans Idioma: En Revista: Biomolecules Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Suécia País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gadolínio / Nefropatias Limite: Humans Idioma: En Revista: Biomolecules Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Suécia País de publicação: Suíça