An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model.

Hedges, Jodi F; Snyder, Deann T; Robison, Amanda; Grifka-Walk, Heather M; Blackwell, Karlin; Shepardson, Kelly; Kominsky, Douglas; Rynda-Apple, Agnieszka; Walcheck, Bruce; Jutila, Mark A

Hedges, Jodi F; Snyder, Deann T; Robison, Amanda; Grifka-Walk, Heather M; Blackwell, Karlin; Shepardson, Kelly; Kominsky, Douglas; Rynda-Apple, Agnieszka; Walcheck, Bruce; Jutila, Mark A.

Afiliação

Hedges JF; Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, United States.
Snyder DT; Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, United States.
Robison A; Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, United States.
Grifka-Walk HM; Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, United States.
Blackwell K; Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, United States.
Shepardson K; Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, United States.
Kominsky D; Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, United States.
Rynda-Apple A; Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, United States.
Walcheck B; Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, MN, United States.
Jutila MA; Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, United States.

Front Immunol ; 13: 918881, 2022.

Article em En | MEDLINE | ID: mdl-35757773

Assuntos

Proteína ADAM17; Anticorpos Neutralizantes; COVID-19; SARS-CoV-2; Proteína ADAM17/antagonistas & inibidores; Proteína ADAM17/imunologia; Enzima de Conversão de Angiotensina 2/metabolismo; Animais; Anticorpos Neutralizantes/imunologia; Anticorpos Neutralizantes/farmacologia; COVID-19/imunologia; COVID-19/terapia; COVID-19/virologia; Modelos Animais de Doenças; Humanos; Camundongos; Camundongos Transgênicos; Peptidil Dipeptidase A/metabolismo; SARS-CoV-2/imunologia; Carga Viral

Palavras-chave

ADAM19; COVID-19; SARS-CoV-2; inflammation; lung; mouse model; virus

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Neutralizantes / Proteína ADAM17 / SARS-CoV-2 / COVID-19 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Front Immunol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Suíça

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