Multivalent NHS-activated acrylates for orthogonal site-selective functionalisation of peptides at cysteine residues.
Chem Commun (Camb)
; 58(57): 7928-7931, 2022 Jul 14.
Article
em En
| MEDLINE
| ID: mdl-35758206
ABSTRACT
The site-selective chemical appendage of multiple functionalities on a native peptide backbone is a highly demanding and complex tool of modern chemical biology. Here, novel NHS-activated acrylates were designed to hold various payloads in a single bioconjugation handle that is able to site-selectively and orthogonally target the N-terminal cysteine of peptides.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acrilatos
/
Cisteína
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Portugal