Hypothesis: By-products of vascular disruption carried in the CSF affect prenatal brain development.
Birth Defects Res
; 114(15): 847-854, 2022 09 01.
Article
em En
| MEDLINE
| ID: mdl-35775635
ABSTRACT
Prenatal CNS disruptions can be associated with physically separate findings. Examples include cognitive issues in septo-optic dysplasia and sporadic and WNT1-related unilateral cerebellar hypoplasia, and physical findings such as thinning of the corpus callosum, ventriculomegaly, hippocampal abnormalities, olfactory tract and bulb hypoplasia, and distant cortical dysplasias with schizencephaly. Similar effects to toxicities with intraventricular hemorrhage in prematurity could occur earlier in development. CSF transportation of disruption by-products would provide access to vulnerable areas through inflammatory effects on blood-brain barrier permeability. Outcomes are influenced by location and volume of byproducts in the CSF, timing, transport, and inflammatory responses. A particular association of vermis disruption with cognitive issues may be related to CSF flow distortions that avoid toxin dilutions in the third ventricle. Symmetrical contralateral cortical dysplasia with schizencephaly may reflect immunovascular field-related vulnerabilities seen in situations such as vitiligo.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Displasia Septo-Óptica
/
Esquizencefalia
/
Malformações do Sistema Nervoso
Limite:
Humans
Idioma:
En
Revista:
Birth Defects Res
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos