Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis.
Aging Cell
; 21(8): e13662, 2022 08.
Article
em En
| MEDLINE
| ID: mdl-35778837
ABSTRACT
Osteoarthritis (OA) is the most common age-related joint disorder with no effective therapy. According to the World Health Organization, OA affects over 500 million people and is characterized by degradation of cartilage and other joint tissues, severe pain, and impaired mobility. Mitochondrial dysfunction contributes to OA pathology. However, interventions to rescue mitochondrial defects in human OA are not available. Urolithin A (Mitopure) is a natural postbiotic compound that promotes mitophagy and mitochondrial function and beneficially impacts muscle health in preclinical models of aging and in elderly and middle-aged humans. Here, we showed that Urolithin A improved mitophagy and mitochondrial respiration in primary chondrocytes from joints of both healthy donors and OA patients. Furthermore, Urolithin A reduced disease progression in a mouse model of OA, decreasing cartilage degeneration, synovial inflammation, and pain. These improvements were associated with increased mitophagy and mitochondrial content, in joints of OA mice. These findings indicate that UA promotes joint mitochondrial health, alleviates OA pathology, and supports Urolithin A's potential to improve mobility with beneficial effects on structural damage in joints.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cartilagem Articular
/
Osteoartrite do Joelho
Tipo de estudo:
Prognostic_studies
Limite:
Aged
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Animals
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Humans
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Middle aged
Idioma:
En
Revista:
Aging Cell
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Suíça