Assessment of metabolic activation of felbamate in chimeric mice with humanized liver in combination with in vitro metabolic assays.

Sato, Koya; Sanoh, Seigo; Ishida, Yuji; Tateno, Chise; Ohta, Shigeru; Kotake, Yaichiro

Sato, Koya; Sanoh, Seigo; Ishida, Yuji; Tateno, Chise; Ohta, Shigeru; Kotake, Yaichiro.

Afiliação

Sato K; Graduate School of Biomedical and Health Sciences, Hiroshima University.
Sanoh S; Non-Clinical Regulatory Science, Applied Research & Operations, Astellas Pharma Inc.
Ishida Y; Graduate School of Biomedical and Health Sciences, Hiroshima University.
Tateno C; School of Pharmaceutical Sciences, Wakayama Medical University.
Ohta S; R&D Dept., PhoenixBio, Co., Ltd.
Kotake Y; Research Center for Hepatology and Gastroenterology, Hiroshima University.

J Toxicol Sci ; 47(7): 277-288, 2022.

Article em En | MEDLINE | ID: mdl-35786679

Assuntos

Isoenzimas; Fígado; Ativação Metabólica; Animais; Modelos Animais de Doenças; Felbamato; Glutationa; Humanos; Camundongos

Palavras-chave

Chimeric mice with humanized liver; Felbamate; Liver toxicity; Mass spectrometry imaging; Reactive metabolite

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Isoenzimas / Fígado Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Toxicol Sci Ano de publicação: 2022 Tipo de documento: Article País de publicação: Japão

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