Human Down syndrome microglia are up for a synaptic feast.
Cell Stem Cell
; 29(7): 1007-1008, 2022 07 07.
Article
em En
| MEDLINE
| ID: mdl-35803219
ABSTRACT
In this issue of Cell Stem Cell, Jin et al. report that human Down syndrome microglia exhibit enhanced synaptic engulfment and accelerated tau-induced cellular senescence in human-mouse chimeric brains. They show that inhibiting interferon signaling rescues both developmental and tau-associated phenotypes, rendering it a potential therapeutic target for Down syndrome.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Down
/
Microglia
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Stem Cell
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos