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Nickel-Catalyzed Three-Component Cross-Electrophile Coupling of 1,3-Dienes with Aldehydes and Aryl Bromides.
Qi, Ya-Qiong; Liu, Shuai; Xu, Yan; Li, Yang; Su, Tong; Ni, Hai-Liang; Gao, Yuanji; Yu, Wenhao; Cao, Peng; Hu, Ping; Zhao, Ke-Qing; Wang, Bi-Qin; Chen, Bin.
Afiliação
  • Qi YQ; College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, People's Republic of China.
  • Liu S; College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, People's Republic of China.
  • Xu Y; College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, People's Republic of China.
  • Li Y; College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, People's Republic of China.
  • Su T; College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, People's Republic of China.
  • Ni HL; College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, People's Republic of China.
  • Gao Y; College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, People's Republic of China.
  • Yu W; College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, People's Republic of China.
  • Cao P; College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, People's Republic of China.
  • Hu P; College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, People's Republic of China.
  • Zhao KQ; College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, People's Republic of China.
  • Wang BQ; College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, People's Republic of China.
  • Chen B; College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, People's Republic of China.
Org Lett ; 24(28): 5023-5028, 2022 07 22.
Article em En | MEDLINE | ID: mdl-35822901
ABSTRACT
We herein report a Ni-catalyzed three-component cross-electrophile coupling of 1,3-dienes with aldehydes and aryl bromides using manganese metal as the reducing agent. This efficient protocol accomplishes dicarbofunctionalization of 1,3-dienes to synthesize diverse structural 1,4-disubstituted homoallylic alcohols by forming two new C-C bonds in one time. Mechanistic study suggests that an allyl-nickel(I) species is involved in the catalytic cycle.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aldeídos / Níquel Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aldeídos / Níquel Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2022 Tipo de documento: Article