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Aspirin attenuates the expression of adhesion molecules, risk of obesity, and adipose tissue inflammation in high-fat diet-induced obese mice.
Roy, Sourav; Bhowmik, Dipty Rani; Begum, Rahima; Amin, Mohammad Tohidul; Islam, Md Aminul; Ahmed, Firoz; Hossain, Mohammad Salim.
Afiliação
  • Roy S; Department of Pharmacy, Noakhali Science and Technology University, Noakhlai 3814, Bangladesh.
  • Bhowmik DR; Department of Pharmacy, Noakhali Science and Technology University, Noakhlai 3814, Bangladesh.
  • Begum R; Department of Pharmacy, Noakhali Science and Technology University, Noakhlai 3814, Bangladesh.
  • Amin MT; Department of Pharmacy, Noakhali Science and Technology University, Noakhlai 3814, Bangladesh.
  • Islam MA; Department of Microbiology, Noakahli Science and Technology University, Noakhali 3814, Bangladesh.
  • Ahmed F; Department of Microbiology, Noakahli Science and Technology University, Noakhali 3814, Bangladesh.
  • Hossain MS; Department of Pharmacy, Noakhali Science and Technology University, Noakhlai 3814, Bangladesh. Electronic address: pharmasalim@yahoo.com.
Prostaglandins Other Lipid Mediat ; 162: 106664, 2022 10.
Article em En | MEDLINE | ID: mdl-35843503
ABSTRACT
The prevalence of obesity is increasing at an alarming rate and keeps on being one of the significant challenges of this century. Obesity promotes adipose tissue hypertrophy and causes the release of different pro-inflammatory cytokines, playing a significant role in the pathophysiology of metabolic syndrome. Aspirin is known as a potent anti-inflammatory drug, but its role in adipogenesis, adipocyte-specific inflammation, and metabolic syndrome is not well characterized. Thus, in this experiment, we aimed to determine the effect of low-dose aspirin on obesity, obesity-induced inflammation, and metabolic syndrome. High-fat diet-induced obese female mice (Swiss Albino) were used in our study. Mice were fed on a normal diet, a high-fat diet, and a low dose of aspirin (LDA) in the presence of a high-fat diet for 11 weeks. Body weight, lipid profile, adipose tissue size, and inflammatory status were analyzed after that period. The ∆∆CT method was used to calculate the relative mRNA expression of target genes. Treatment with a low dose of aspirin resulted in a significant reduction of body weight, visceral fat mass and serum total cholesterols, serum and adipose tissue triglycerides, and blood glucose levels in high-fat diet-induced obese mice compared to the untreated obese group. Consistent with these biochemical results, a significant reduction in mRNA expression of different genes like PPARγ, GLUT4, IL-6, TNFα, MCP-1, ICAM-I, and VCAM-I associated with adipogenesis and inflammation were noticed. Overall, current study findings indicate that low-dose aspirin reduces obesity, hyperlipidemia, adipocyte-specific inflammation, and metabolic syndrome in high-fat diet-induced obese mice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome Metabólica / Dieta Hiperlipídica Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Prostaglandins Other Lipid Mediat Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Bangladesh

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome Metabólica / Dieta Hiperlipídica Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Prostaglandins Other Lipid Mediat Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Bangladesh