Metal-Free Regioselective N2-Arylation of 1H-Tetrazoles with Diaryliodonium Salts.
J Org Chem
; 87(15): 9782-9796, 2022 08 05.
Article
em En
| MEDLINE
| ID: mdl-35849501
ABSTRACT
We describe a simple, metal-free regioselective N2-arylation strategy for 5-substituted-1H-tetrazoles with diaryliodonium salts to access 2-aryl-5-substituted-tetrazoles. Diaryliodonium salts with a wide range of both electron-rich and previously challenged electron-deficient aryl groups are applicable in this method. Diversely functionalized tetrazoles are tolerable also. We have devised a one-pot system to synthesize 2,5-diaryl-tetrazoles directly from nitriles. The synthetic utility of this method is furthered extended to late-stage arylation of two biologically active molecules.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oniocompostos
/
Sais
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Índia