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Nanomedicine platform for targeting activated neutrophils and neutrophil-platelet complexes using an α1-antitrypsin-derived peptide motif.
Cruz, Michelle A; Bohinc, Dillon; Andraska, Elizabeth A; Alvikas, Jurgis; Raghunathan, Shruti; Masters, Nicole A; van Kleef, Nadine D; Bane, Kara L; Hart, Kathryn; Medrow, Kathryn; Sun, Michael; Liu, Haitao; Haldeman, Shannon; Banerjee, Ankush; Lessieur, Emma M; Hageman, Kara; Gandhi, Agharnan; de la Fuente, Maria; Nieman, Marvin T; Kern, Timothy S; Maas, Coen; de Maat, Steven; Neeves, Keith B; Neal, Matthew D; Sen Gupta, Anirban; Stavrou, Evi X.
Afiliação
  • Cruz MA; Department of Pathology, Immunology Training Program, CWRU School of Medicine, Cleveland, OH, USA.
  • Bohinc D; Department of Medicine, Hematology and Oncology Division, CWRU School of Medicine, Cleveland, OH, USA.
  • Andraska EA; Department of Surgery, Division of Vascular Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Alvikas J; Department of Surgery, Pittsburgh Trauma Research Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Raghunathan S; Department of Biomedical Engineering, Case Western Reserve University (CWRU), Cleveland, OH, USA.
  • Masters NA; Department of Civil and Environmental Engineering, Colorado School of Mines, Golden, CO, USA.
  • van Kleef ND; CDL Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Bane KL; Department of Medicine, Hematology and Oncology Division, CWRU School of Medicine, Cleveland, OH, USA.
  • Hart K; Department of Biomedical Engineering, Case Western Reserve University (CWRU), Cleveland, OH, USA.
  • Medrow K; Department of Biomedical Engineering, Case Western Reserve University (CWRU), Cleveland, OH, USA.
  • Sun M; Department of Biomedical Engineering, Case Western Reserve University (CWRU), Cleveland, OH, USA.
  • Liu H; Department of Ophthalmology, Children's Hospital of University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Haldeman S; Department of Surgery, Pittsburgh Trauma Research Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Banerjee A; Department of Biomedical Engineering, Case Western Reserve University (CWRU), Cleveland, OH, USA.
  • Lessieur EM; Center for Translational Vision Research, Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA, USA.
  • Hageman K; Department of Biomedical Engineering, Case Western Reserve University (CWRU), Cleveland, OH, USA.
  • Gandhi A; Department of Medicine, Hematology and Oncology Division, CWRU School of Medicine, Cleveland, OH, USA.
  • de la Fuente M; Department of Pharmacology, CWRU School of Medicine, Cleveland, OH, USA.
  • Nieman MT; Department of Pharmacology, CWRU School of Medicine, Cleveland, OH, USA.
  • Kern TS; Center for Translational Vision Research, Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA, USA.
  • Maas C; Veterans Administration Medical Center Research Service, Long Beach, CA, USA.
  • de Maat S; CDL Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Neeves KB; CDL Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Neal MD; Department of Bioengineering and Pediatrics, Section of Hematology, Oncology, and Bone Marrow Transplant Hemophilia and Thrombosis Center, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
  • Sen Gupta A; Department of Surgery, Pittsburgh Trauma Research Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Stavrou EX; Department of Pathology, Immunology Training Program, CWRU School of Medicine, Cleveland, OH, USA. axs262@case.edu.
Nat Nanotechnol ; 17(9): 1004-1014, 2022 09.
Article em En | MEDLINE | ID: mdl-35851383
ABSTRACT
Targeted drug delivery to disease-associated activated neutrophils can provide novel therapeutic opportunities while avoiding systemic effects on immune functions. We created a nanomedicine platform that uniquely utilizes an α1-antitrypsin-derived peptide to confer binding specificity to neutrophil elastase on activated neutrophils. Surface decoration with this peptide enabled specific anchorage of nanoparticles to activated neutrophils and platelet-neutrophil aggregates, in vitro and in vivo. Nanoparticle delivery of a model drug, hydroxychloroquine, demonstrated significant reduction of neutrophil activities in vitro and a therapeutic effect on murine venous thrombosis in vivo. This innovative approach of cell-specific and activation-state-specific targeting can be applied to several neutrophil-driven pathologies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Elastase de Leucócito / Deficiência de alfa 1-Antitripsina Limite: Animals / Humans Idioma: En Revista: Nat Nanotechnol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Elastase de Leucócito / Deficiência de alfa 1-Antitripsina Limite: Animals / Humans Idioma: En Revista: Nat Nanotechnol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos