Mononucleotide A-repeats may Play a Regulatory Role in Endothermic Housekeeping Genes.
Evol Bioinform Online
; 18: 11769343221110656, 2022.
Article
em En
| MEDLINE
| ID: mdl-35860694
ABSTRACT
Background:
Coding and non-coding short tandem repeats (STRs) facilitate a great diversity of phenotypic traits. The imbalance of mononucleotide A-repeats around transcription start sites (TSSs) was found in 3 mammals H. sapiens, M. musculus, and R. norvegicus. PrincipalFindings:
We found that the imbalance pattern originated in some vertebrates. A similar pattern was observed in mammals and birds, but not in amphibians and reptiles. We proposed that the enriched A-repeats upstream of TSSs is a novel hallmark of endotherms or warm-blooded animals. Gene ontology analysis indicates that the primary function of upstream A-repeats involves metabolism, cellular transportation, and sensory perception (smell and chemical stimulus) through housekeeping genes.Conclusions:
Upstream A-repeats may play a regulatory role in the metabolic process of endothermic animals.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Evol Bioinform Online
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Tailândia