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Off-Stoichiometric Thiol-Ene Chemistry to Dendritic Nanogel Therapeutics.
Zhang, Yuning; Andrén, Oliver C J; Nordström, Randi; Fan, Yanmiao; Malmsten, Martin; Mongkhontreerat, Surinthra; Malkoch, Michael.
Afiliação
  • Zhang Y; KTH Royal Institute of Technology Department of Fibre and Polymer Technology SE-100 44 Stockholm Sweden.
  • Andrén OCJ; KTH Royal Institute of Technology Department of Fibre and Polymer Technology SE-100 44 Stockholm Sweden.
  • Nordström R; Department of Pharmacy Uppsala University SE-751 23 Uppsala Sweden.
  • Fan Y; KTH Royal Institute of Technology Department of Fibre and Polymer Technology SE-100 44 Stockholm Sweden.
  • Malmsten M; Department of Pharmacy Uppsala University SE-751 23 Uppsala Sweden.
  • Mongkhontreerat S; Sweden Polymer Factory Sweden AB SE-114 28 Stockholm Sweden.
  • Malkoch M; KTH Royal Institute of Technology Department of Fibre and Polymer Technology SE-100 44 Stockholm Sweden.
Adv Funct Mater ; 29(18): 1806693, 2019 May 02.
Article em En | MEDLINE | ID: mdl-35865651
A novel platform of dendritic nanogels is herein presented, capitalizing on the self-assembly of allyl-functional polyesters based on dendritic-linear-dendritic amphiphiles followed by simple cross-linking with complementary monomeric thiols via UV initiated off-stoichiometric thiol-ene chemistry. The facile approach enabled multigram creation of allyl reactive nanogel precursors, in the size range of 190-295 nm, being readily available for further modifications to display a number of core functionalities while maintaining the size distribution and characteristics of the master batch. The nanogels are evaluated as carriers of a spread of chemotherapeutics by customizing the core to accommodate each individual cargo. The resulting nanogels are biocompatible, displaying diffusion controlled release of cargo, maintained therapeutic efficacy, and decreased cargo toxic side effects. Finally, the nanogels are found to successfully deliver pharmaceuticals into a 3D pancreatic spheroids tumor model.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Adv Funct Mater Ano de publicação: 2019 Tipo de documento: Article País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Adv Funct Mater Ano de publicação: 2019 Tipo de documento: Article País de publicação: Alemanha