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Selective targeting of metastatic ovarian cancer using an engineered anthrax prodrug activated by membrane-anchored serine proteases.
Duru, Nadire; Pawar, Nisha R; Martin, Erik W; Buzza, Marguerite S; Conway, Gregory D; Lapidus, Rena G; Liu, Shihui; Reader, Jocelyn; Rao, Gautam G; Roque, Dana M; Leppla, Stephen H; Antalis, Toni M.
Afiliação
  • Duru N; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Pawar NR; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Martin EW; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Buzza MS; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Conway GD; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Lapidus RG; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Liu S; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Reader J; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Rao GG; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Roque DM; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Leppla SH; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Antalis TM; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201.
Proc Natl Acad Sci U S A ; 119(28): e2201423119, 2022 07 12.
Article em En | MEDLINE | ID: mdl-35867758
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Toxinas Bacterianas / Pró-Fármacos / Serina Proteases / Antígenos de Bactérias / Antineoplásicos Limite: Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Toxinas Bacterianas / Pró-Fármacos / Serina Proteases / Antígenos de Bactérias / Antineoplásicos Limite: Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos