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TREM2 macrophages induced by human lipids drive inflammation in acne lesions.
Do, Tran H; Ma, Feiyang; Andrade, Priscila R; Teles, Rosane; de Andrade Silva, Bruno J; Hu, Chanyue; Espinoza, Alejandro; Hsu, Jer-En; Cho, Chun-Seok; Kim, Myungjin; Xi, Jingyue; Xing, Xianying; Plazyo, Olesya; Tsoi, Lam C; Cheng, Carol; Kim, Jenny; Bryson, Bryan D; O'Neill, Alan M; Colonna, Marco; Gudjonsson, Johann E; Klechevsky, Eynav; Lee, Jun Hee; Gallo, Richard L; Bloom, Barry R; Pellegrini, Matteo; Modlin, Robert L.
Afiliação
  • Do TH; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Ma F; Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles,, Los Angeles, CA 90095, USA.
  • Andrade PR; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Teles R; Institute for Quantitative and Computational Biosciences-The Collaboratory, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • de Andrade Silva BJ; Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles,, Los Angeles, CA 90095, USA.
  • Hu C; Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles,, Los Angeles, CA 90095, USA.
  • Espinoza A; Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles,, Los Angeles, CA 90095, USA.
  • Hsu JE; Institute for Quantitative and Computational Biosciences-The Collaboratory, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Cho CS; Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Kim M; Institute for Quantitative and Computational Biosciences-The Collaboratory, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Xi J; Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Xing X; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  • Plazyo O; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  • Tsoi LC; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  • Cheng C; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.
  • Kim J; Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Bryson BD; Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA.
  • O'Neill AM; Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Colonna M; Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles,, Los Angeles, CA 90095, USA.
  • Gudjonsson JE; Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles,, Los Angeles, CA 90095, USA.
  • Klechevsky E; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Lee JH; Department of Dermatology, University of California San Diego, La Jolla, CA 92093, USA.
  • Gallo RL; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Bloom BR; Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Pellegrini M; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Modlin RL; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Sci Immunol ; 7(73): eabo2787, 2022 07 22.
Article em En | MEDLINE | ID: mdl-35867799
ABSTRACT
Acne affects 1 in 10 people globally, often resulting in disfigurement. The disease involves excess production of lipids, particularly squalene, increased growth of Cutibacterium acnes, and a host inflammatory response with foamy macrophages. By combining single-cell and spatial RNA sequencing as well as ultrahigh-resolution Seq-Scope analyses of early acne lesions on back skin, we identified TREM2 macrophages expressing lipid metabolism and proinflammatory gene programs in proximity to hair follicle epithelium expressing squalene epoxidase. We established that the addition of squalene induced differentiation of TREM2 macrophages in vitro, which were unable to kill C. acnes. The addition of squalene to macrophages inhibited induction of oxidative enzymes and scavenged oxygen free radicals, providing an explanation for the efficacy of topical benzoyl peroxide in the clinical treatment of acne. The present work has elucidated the mechanisms by which TREM2 macrophages and unsaturated lipids, similar to their involvement in atherosclerosis, may contribute to the pathogenesis of acne.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esqualeno / Acne Vulgar Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Sci Immunol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esqualeno / Acne Vulgar Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Sci Immunol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos