<i>N</i>-2-(Phenylamino) Benzamide Derivatives as Dual Inhibitors of COX-2 and Topo I Deter Gastrointestinal Cancers via Targeting Inflammation and Tumor Progression.

Li, Junfang; Hu, Xiaoling; Zhang, Honghua; Peng, Yan; Li, Shuang; Xiong, Yongxia; Jiang, Weifan; Wang, Zhen

N-2-(Phenylamino) Benzamide Derivatives as Dual Inhibitors of COX-2 and Topo I Deter Gastrointestinal Cancers via Targeting Inflammation and Tumor Progression.

Li, Junfang; Hu, Xiaoling; Zhang, Honghua; Peng, Yan; Li, Shuang; Xiong, Yongxia; Jiang, Weifan; Wang, Zhen.

Afiliação

Li J; School of Pharmacy, Lanzhou University, Lanzhou730000, China.
Hu X; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou730000, China.
Zhang H; School of Pharmacy, Lanzhou University, Lanzhou730000, China.
Peng Y; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou730000, China.
Li S; School of Pharmacy, Lanzhou University, Lanzhou730000, China.
Xiong Y; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou730000, China.
Jiang W; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang421001, Hunan, China.
Wang Z; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang421001, Hunan, China.

J Med Chem ; 65(15): 10481-10505, 2022 08 11.

Article em En | MEDLINE | ID: mdl-35868003

Assuntos

Inibidores Enzimáticos/farmacologia; Neoplasias Gastrointestinais; NF-kappa B; Animais; Anti-Inflamatórios/farmacologia; Benzamidas/farmacologia; Benzamidas/uso terapêutico; Ciclo-Oxigenase 2/metabolismo; DNA Topoisomerases Tipo I/farmacologia; Dinoprostona; Inflamação/tratamento farmacológico; Inflamação/metabolismo; Lipopolissacarídeos/farmacologia; Camundongos; NF-kappa B/metabolismo; Transdução de Sinais; Inibidores da Topoisomerase I

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Inibidores Enzimáticos / Neoplasias Gastrointestinais Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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