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Telomere Length and Risk of Incident Fracture and Arthroplasty: Findings From UK Biobank.
Curtis, Elizabeth M; Codd, Veryan; Nelson, Christopher; D'Angelo, Stefania; Wang, Qingning; Allara, Elias; Kaptoge, Stephen; Matthews, Paul M; Tobias, Jonathan H; Danesh, John; Cooper, Cyrus; Samani, Nilesh J; Harvey, Nicholas C.
Afiliação
  • Curtis EM; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
  • Codd V; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
  • Nelson C; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
  • D'Angelo S; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
  • Wang Q; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
  • Allara E; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
  • Kaptoge S; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
  • Matthews PM; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
  • Tobias JH; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Danesh J; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
  • Cooper C; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.
  • Samani NJ; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Harvey NC; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
J Bone Miner Res ; 37(10): 1997-2004, 2022 10.
Article em En | MEDLINE | ID: mdl-35880304
ABSTRACT
We investigated independent associations between telomere length and risk of fracture and arthroplasty in UK Biobank participants. Leukocyte telomere length (LTL) was measured in baseline samples using a validated polymerase chain reaction (PCR) method. We used, in men and women separately, Cox proportional hazards models to calculate the hazard ratio (HR) for incident fracture (any, osteoporotic) or arthroplasty (hip or knee) over 1,186,410 person-years of follow-up. Covariates included age, white cell count, ethnicity, smoking, alcohol, physical activity, and menopause (women). In further analyses we adjusted for either estimated bone mineral density (eBMD) from heel quantitative ultrasound, handgrip strength, gait speed, total fat mass (bioimpedance), or blood biomarkers, all measured at baseline (2006-2010). We studied 59,500 women and 51,895 men, mean ± standard deviation (SD) age 56.4 ± 8.0 and 57.0 ± 8.3 years, respectively. During follow-up there were 5619 fractures; 5285 hip and 4261 knee arthroplasties. In confounder-adjusted models, longer LTL was associated with reduced risk of incident knee arthroplasty in both men (HR/SD 0.93; 95% confidence interval [CI], 0.88-0.97) and women (0.92; 95% CI, 0.88-0.96), and hip arthroplasty in men (0.91; 95% CI, 0.87-0.95), but not women (0.98; 95% CI, 0.94-1.01). Longer LTL was weakly associated with reduced risk of any incident fracture in women (HR/SD 0.96; 95% CI, 0.93-1.00) with less evidence in men (0.98; 95% CI, 0.93-1.02). Associations with incident outcomes were not materially altered by adjustment for heel eBMD, grip strength, gait speed, fat mass, or blood biomarker measures. In this, the largest study to date, longer LTL was associated with lower risk of incident knee or hip arthroplasty, but only weakly associated with lower risk of fracture. The relative risks were low at a population level, but our findings suggest that common factors acting on the myeloid and musculoskeletal systems might influence later life musculoskeletal outcomes. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artroplastia de Quadril / Artroplastia do Joelho / Fraturas Ósseas / Fraturas por Osteoporose / Fraturas do Quadril Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: J Bone Miner Res Assunto da revista: METABOLISMO / ORTOPEDIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artroplastia de Quadril / Artroplastia do Joelho / Fraturas Ósseas / Fraturas por Osteoporose / Fraturas do Quadril Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: J Bone Miner Res Assunto da revista: METABOLISMO / ORTOPEDIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA