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Elevated Transaminases as Predictors of COVID-19 Pneumonia Severity.
Radonjic, Tijana; Milicevic, Ognjen; Jovanovic, Igor; Zdravkovic, Marija; Dukic, Marija; Mandic, Olga Milorad; Bjekic-Macut, Jelica; Markovic, Olivera Borko; Todorovic, Zoran; Brajkovic, Milica; Nikolic, Novica; Klasnja, Slobodan; Popadic, Viseslav; Divac, Anica; Marinkovic, Milica; Alhayek, Nabil; Brankovic, Marija Svetislav.
Afiliação
  • Radonjic T; University Hospital Medical Center Bezanijska Kosa, 11000 Belgrade, Serbia.
  • Milicevic O; Faculty of Medicine, Institute for Medical Statistics and Informatics, University of Belgrade, 11000 Belgrade, Serbia.
  • Jovanovic I; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  • Zdravkovic M; University Hospital Medical Center Bezanijska Kosa, 11000 Belgrade, Serbia.
  • Dukic M; University Hospital Medical Center Bezanijska Kosa, 11000 Belgrade, Serbia.
  • Mandic OM; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  • Bjekic-Macut J; University Hospital Medical Center Bezanijska Kosa, 11000 Belgrade, Serbia.
  • Markovic OB; University Hospital Medical Center Bezanijska Kosa, 11000 Belgrade, Serbia.
  • Todorovic Z; University Hospital Medical Center Bezanijska Kosa, 11000 Belgrade, Serbia.
  • Brajkovic M; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  • Nikolic N; University Hospital Medical Center Bezanijska Kosa, 11000 Belgrade, Serbia.
  • Klasnja S; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  • Popadic V; University Hospital Medical Center Bezanijska Kosa, 11000 Belgrade, Serbia.
  • Divac A; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  • Marinkovic M; University Hospital Medical Center Bezanijska Kosa, 11000 Belgrade, Serbia.
  • Alhayek N; University Hospital Medical Center Bezanijska Kosa, 11000 Belgrade, Serbia.
  • Brankovic MS; University Hospital Medical Center Bezanijska Kosa, 11000 Belgrade, Serbia.
Medicina (Kaunas) ; 58(7)2022 Jun 23.
Article em En | MEDLINE | ID: mdl-35888561
BACKGROUND: This study aimed to calculate the frequency of elevated liver enzymes in hospitalized patients with coronavirus disease 2019 (COVID-19) infection and to test if liver enzyme biochemistry levels on admission could predict the computed tomography (CT) scan severity score of bilateral interstitial pneumonia. METHODS: This single-center study comprised of 323 patients including their demographic data, laboratory analyses, and radiological findings. All the information was taken from electronic health records, followed by statistical analysis. RESULTS: Out of 323 patients, 115 of them (35.60%) had aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) over 40 U/L on admission. AST was the best predictor of CT scan severity score of bilateral interstitial pneumonia (R2 = 0.313, Adjusted R2 = 0.299). CT scan severity score in the peak of the infection could be predicted with the value of AST, neutrophils, platelets, and monocytes count (R2 = 0.535, Adjusted R2 = 0.495). CONCLUSION: AST, neutrophils, platelets, and monocytes count on admission can account for almost half (49.5%) of the variability in CT scan severity score at peak of the disease, predicting the extensiveness of interstitial pneumonia related to COVID-19 infection. Liver enzymes should be closely monitored in order to stratify COVID-19 patients with a higher risk of developing severe forms of the disease and to plan the beforehand step-up treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia / COVID-19 Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Medicina (Kaunas) Assunto da revista: MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia / COVID-19 Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Medicina (Kaunas) Assunto da revista: MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de publicação: Suíça