Role of a "Magic" Methyl: 2'-Deoxy-2'-&#945;-F-2'-ß-<i>C</i>-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5'-Phosphate Mimics and Mitigation of Off-Target Effects.

Guenther, Dale C; Mori, Shohei; Matsuda, Shigeo; Gilbert, Jason A; Willoughby, Jennifer L S; Hyde, Sarah; Bisbe, Anna; Jiang, Yongfeng; Agarwal, Saket; Madaoui, Mimouna; Janas, Maja M; Charisse, Klaus; Maier, Martin A; Egli, Martin; Manoharan, Muthiah

Role of a "Magic" Methyl: 2'-Deoxy-2'-α-F-2'-ß-C-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5'-Phosphate Mimics and Mitigation of Off-Target Effects.

Guenther, Dale C; Mori, Shohei; Matsuda, Shigeo; Gilbert, Jason A; Willoughby, Jennifer L S; Hyde, Sarah; Bisbe, Anna; Jiang, Yongfeng; Agarwal, Saket; Madaoui, Mimouna; Janas, Maja M; Charisse, Klaus; Maier, Martin A; Egli, Martin; Manoharan, Muthiah.

Afiliação

Guenther DC; Alnylam Pharmaceuticals, 675 West Kendall, Cambridge, Massachusetts 02142, United States.
Mori S; Alnylam Pharmaceuticals, 675 West Kendall, Cambridge, Massachusetts 02142, United States.
Matsuda S; Alnylam Pharmaceuticals, 675 West Kendall, Cambridge, Massachusetts 02142, United States.
Gilbert JA; Alnylam Pharmaceuticals, 675 West Kendall, Cambridge, Massachusetts 02142, United States.
Willoughby JLS; Alnylam Pharmaceuticals, 675 West Kendall, Cambridge, Massachusetts 02142, United States.
Hyde S; Alnylam Pharmaceuticals, 675 West Kendall, Cambridge, Massachusetts 02142, United States.
Bisbe A; Alnylam Pharmaceuticals, 675 West Kendall, Cambridge, Massachusetts 02142, United States.
Jiang Y; Alnylam Pharmaceuticals, 675 West Kendall, Cambridge, Massachusetts 02142, United States.
Agarwal S; Alnylam Pharmaceuticals, 675 West Kendall, Cambridge, Massachusetts 02142, United States.
Madaoui M; Alnylam Pharmaceuticals, 675 West Kendall, Cambridge, Massachusetts 02142, United States.
Janas MM; Alnylam Pharmaceuticals, 675 West Kendall, Cambridge, Massachusetts 02142, United States.
Charisse K; Alnylam Pharmaceuticals, 675 West Kendall, Cambridge, Massachusetts 02142, United States.
Maier MA; Alnylam Pharmaceuticals, 675 West Kendall, Cambridge, Massachusetts 02142, United States.
Egli M; Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, United States.
Manoharan M; Alnylam Pharmaceuticals, 675 West Kendall, Cambridge, Massachusetts 02142, United States.

J Am Chem Soc ; 144(32): 14517-14534, 2022 08 17.

Article em En | MEDLINE | ID: mdl-35921401

Assuntos

Organofosfonatos; Nucleotídeos de Pirimidina; Animais; Lipossomos; Camundongos; Modelos Moleculares; Nanopartículas; Conformação de Ácido Nucleico; Nucleosídeos; Nucleotídeos; Oligonucleotídeos; Fosfatos; Interferência de RNA; RNA Interferente Pequeno/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nucleotídeos de Pirimidina / Organofosfonatos Limite: Animals Idioma: En Revista: J Am Chem Soc Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

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