Fluorescence Lifetime Measurement of Prefibrillar Sickle Hemoglobin Oligomers as a Platform for Drug Discovery in Sickle Cell Disease.

Vunnam, Nagamani; Hansen, Scott; Williams, Dillon C; Been, MaryJane Olivia; Lo, Chih Hung; Pandey, Anil K; Paulson, Carolyn N; Rohde, John A; Thomas, David D; Sachs, Jonathan N; Wood, David K

Vunnam, Nagamani; Hansen, Scott; Williams, Dillon C; Been, MaryJane Olivia; Lo, Chih Hung; Pandey, Anil K; Paulson, Carolyn N; Rohde, John A; Thomas, David D; Sachs, Jonathan N; Wood, David K.

Afiliação

Vunnam N; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Hansen S; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Williams DC; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Been MO; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Lo CH; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Pandey AK; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Paulson CN; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Rohde JA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Thomas DD; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Sachs JN; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Wood DK; Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Biomacromolecules ; 23(9): 3822-3830, 2022 09 12.

Article em En | MEDLINE | ID: mdl-35944154

Assuntos

Anemia Falciforme; Hemoglobina Falciforme; Anemia Falciforme/tratamento farmacológico; Anemia Falciforme/metabolismo; Descoberta de Drogas; Hemoglobina Falciforme/química; Hemoglobina Falciforme/metabolismo; Hemoglobinas; Humanos; Oxigênio/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobina Falciforme / Anemia Falciforme Aspecto: Patient_preference Limite: Humans Idioma: En Revista: Biomacromolecules Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

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