8-Hydroxyquinoline a natural chelating agent from Streptomyces spp. inhibits A549 lung cancer cell lines via BCL2/STAT3 regulating pathways.

Balthazar, Joseph Devadass; Soosaimanickam, Maria Packiam; Emmanuel, C; Krishnaraj, Thirugnansambantham; Sheikh, Abdullah; Alghafis, Saleh Fahad; Ibrahim, Hairul-Islam Mohamed

Balthazar, Joseph Devadass; Soosaimanickam, Maria Packiam; Emmanuel, C; Krishnaraj, Thirugnansambantham; Sheikh, Abdullah; Alghafis, Saleh Fahad; Ibrahim, Hairul-Islam Mohamed.

Afiliação

Balthazar JD; Division of Microbiology and Biotechnology, Entomology Research Institute, Loyola College, Chennai, Tamil Nadu, 600 034, India. drjosephdb@loyolacollege.edu.
Soosaimanickam MP; Division of Microbiology and Biotechnology, Entomology Research Institute, Loyola College, Chennai, Tamil Nadu, 600 034, India.
Emmanuel C; PG and Research Department of Advanced Zoology and Biotechnology, Loyola College, Chennai, Tamil Nadu, 600 034, India.
Krishnaraj T; Gleneagles Global Health City, Perumbakkam, Chennai, Tamil Nadu, 600 100, India.
Sheikh A; Pondicherry Centre for Biological Science and Educational Trust, Sundararaja Nagar, Pondicherry, 605004, India.
Alghafis SF; Department of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai, India.
Ibrahim HM; Camel Research Center, King Faisal University, P.O. Box 400, AlHufuf, 31982, Al-Ahsa, Saudi Arabia.

World J Microbiol Biotechnol ; 38(10): 182, 2022 Aug 12.

Article em En | MEDLINE | ID: mdl-35953631

Assuntos

Neoplasias Pulmonares; Streptomyces; Células A549; Apoptose; Caspases; Linhagem Celular Tumoral; Proliferação de Células; Quelantes/uso terapêutico; Humanos; Neoplasias Pulmonares/tratamento farmacológico; Oxiquinolina/uso terapêutico; Proteínas Proto-Oncogênicas c-bcl-2/genética; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Proteínas Proto-Oncogênicas c-bcl-2/uso terapêutico; Fator de Transcrição STAT3/metabolismo; Fator de Transcrição STAT3/uso terapêutico; Solo; Streptomyces/metabolismo

Palavras-chave

A549; Anticancer; Apoptosis; Dual staining; P53; STAT3; Streptomyces spp.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Streptomyces / Neoplasias Pulmonares Limite: Humans Idioma: En Revista: World J Microbiol Biotechnol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia País de publicação: Alemanha

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