Influence of antioxidant enzymes in reduction of optic disc edema in experimental optic neuritis.
J Free Radic Biol Med
; 2(5-6): 349-57, 1986.
Article
em En
| MEDLINE
| ID: mdl-3598064
ABSTRACT
Acute experimental allergic optic neuritis was induced in 18 adult strain-13 guinea pigs. The animals were divided into three groups. The first group of six animals received intraperitoneal injections of saline, the second group received superoxide dismutase (SOD), and the third group received catalase, given daily, starting 1 week after encephalogenic myelin sensitization. Morphometric analysis of longitudinal histopathologic sections of the optic nerve head revealed that the animals treated with the antioxidant enzyme catalase had a statistically significant reduction of optic disc edema when compared to the saline-treated group. Although animals treated with SOD had less optic disc swelling than the saline-treated controls, the differences were not statistically significant. These results indicate that detoxification of hydrogen peroxide, released by invading inflammatory cells, can reduce the severity of axonal swelling within the optic nerve head.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Superóxido Dismutase
/
Catalase
/
Neurite Óptica
/
Antioxidantes
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
J Free Radic Biol Med
Assunto da revista:
BIOLOGIA
/
MEDICINA
/
TOXICOLOGIA
Ano de publicação:
1986
Tipo de documento:
Article
País de publicação:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA