Genotoxicity evaluation of a valsartan-related complex N-nitroso-impurity.

Glowienke, Susanne; Onken, Ulrich; Elhajouji, Azeddine; Muthusamy, Sasikumar; Sangana, Ramachandra; Martus, Hans-Joerg; Bedman, Timothy; Hartmann, Andreas

Glowienke, Susanne; Onken, Ulrich; Elhajouji, Azeddine; Muthusamy, Sasikumar; Sangana, Ramachandra; Martus, Hans-Joerg; Bedman, Timothy; Hartmann, Andreas.

Afiliação

Glowienke S; Novartis AG, NIBR, Pre-clinical Safety, Basel, Switzerland. Electronic address: susanne.glowienke@novartis.com.
Onken U; Novartis AG, GDD, Chemical & Analytical Development, Basel, Switzerland.
Elhajouji A; Novartis AG, NIBR, Pre-clinical Safety, Basel, Switzerland.
Muthusamy S; Novartis Healthcare Private Limited, NIBR, Pre-clinical Safety, Hyderabad, India.
Sangana R; Novartis Pharmaceuticals, NIBR, PK Sciences, Cambridge Boston, USA.
Martus HJ; Novartis AG, NIBR, Pre-clinical Safety, Basel, Switzerland.
Bedman T; Novartis Pharmaceuticals, NIBR, PK Sciences, Cambridge Boston, USA.
Hartmann A; Novartis AG, NIBR, Pre-clinical Safety, Basel, Switzerland.

Regul Toxicol Pharmacol ; 134: 105245, 2022 Oct.

Article em En | MEDLINE | ID: mdl-35988810

Assuntos

Mutagênicos; Nitrosaminas; Animais; Dano ao DNA; Camundongos; Mutagênese; Mutagênicos/toxicidade; Valsartana/química

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mutagênicos / Nitrosaminas Limite: Animals Idioma: En Revista: Regul Toxicol Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de publicação: Holanda

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