Mitochondrial oxygen sensing of acute hypoxia in specialized cells - Is there a unifying mechanism?
Biochim Biophys Acta Bioenerg
; 1863(8): 148911, 2022 11 01.
Article
em En
| MEDLINE
| ID: mdl-35988811
ABSTRACT
Acclimation to acute hypoxia through cardiorespiratory responses is mediated by specialized cells in the carotid body and pulmonary vasculature to optimize systemic arterial oxygenation and thus oxygen supply to the tissues. Acute oxygen sensing by these cells triggers hyperventilation and hypoxic pulmonary vasoconstriction which limits pulmonary blood flow through areas of low alveolar oxygen content. Oxygen sensing of acute hypoxia by specialized cells thus is a fundamental pre-requisite for aerobic life and maintains systemic oxygen supply. However, the primary oxygen sensing mechanism and the question of a common mechanism in different specialized oxygen sensing cells remains unresolved. Recent studies unraveled basic oxygen sensing mechanisms involving the mitochondrial cytochrome c oxidase subunit 4 isoform 2 that is essential for the hypoxia-induced release of mitochondrial reactive oxygen species and subsequent acute hypoxic responses in both, the carotid body and pulmonary vasculature. This review compares basic mitochondrial oxygen sensing mechanisms in the pulmonary vasculature and the carotid body.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Complexo IV da Cadeia de Transporte de Elétrons
Limite:
Humans
Idioma:
En
Revista:
Biochim Biophys Acta Bioenerg
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Alemanha