Factors Affecting the Metabolic Conversion of Ciprofloxacin and Exposure to Its Main Active Metabolites in Critically Ill Patients: Population Pharmacokinetic Analysis of Desethylene Ciprofloxacin.

Síma, Martin; Bobek, Daniel; Cihlárová, Petra; Rysánek, Pavel; Rousarová, Jaroslava; Berousek, Jan; Kuchar, Martin; Vymazal, Tomás; Slanar, Ondrej

Síma, Martin; Bobek, Daniel; Cihlárová, Petra; Rysánek, Pavel; Rousarová, Jaroslava; Berousek, Jan; Kuchar, Martin; Vymazal, Tomás; Slanar, Ondrej.

Afiliação

Síma M; Department of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital, 128 00 Prague, Czech Republic.
Bobek D; Department of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital, 128 00 Prague, Czech Republic.
Cihlárová P; Forensic Laboratory of Biologically Active Substances, Department of Chemistry of Natural Compounds, University of Chemistry and Technology, 166 28 Prague, Czech Republic.
Rysánek P; Department of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital, 128 00 Prague, Czech Republic.
Rousarová J; Department of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital, 128 00 Prague, Czech Republic.
Berousek J; Department of Anesthesiology and ICM, Second Faculty of Medicine, Charles University and Motol University Hospital, 150 06 Prague, Czech Republic.
Kuchar M; Forensic Laboratory of Biologically Active Substances, Department of Chemistry of Natural Compounds, University of Chemistry and Technology, 166 28 Prague, Czech Republic.
Vymazal T; Department of Anesthesiology and ICM, Second Faculty of Medicine, Charles University and Motol University Hospital, 150 06 Prague, Czech Republic.
Slanar O; Department of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital, 128 00 Prague, Czech Republic.

Pharmaceutics ; 14(8)2022 Aug 04.

Article em En | MEDLINE | ID: mdl-36015253

Palavras-chave

desethylene ciprofloxacin; formyl ciprofloxacin; gene polymorphism; oxociprofloxacin; pharmacogenetics; population pharmacokinetics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Pharmaceutics Ano de publicação: 2022 Tipo de documento: Article País de afiliação: República Tcheca País de publicação: Suíça

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