Alkaloids, sesquiterpenoids and hybrids of terpenoid with p-hydroxycinnamic acid from Ganoderma sinensis and their biological evaluation.
Phytochemistry
; 203: 113379, 2022 Nov.
Article
em En
| MEDLINE
| ID: mdl-36029844
ABSTRACT
The fruiting bodies of Ganoderma sinensis are used as food raw materials of marketed healthcare products. To gain an insight into the chemical and biological profling of G. sinensis, twenty-five compounds including eleven undescribed ones (ganodermasines AâK) and fourteen known ones were isolated. Among them, ganodermasines AâD are undescribed diketopiperazine alkaloids, ganodermasines E and F are alkaloids containing a pyridine. The structures of undescribed compounds were identified by spectroscopic, computational, and crystallographic methods. The results of acetylcholinesterase (AchE) inhibitory activity show that ganodermasines I and J could inhibit AchE with IC50 values of 26.05 and 20.40 µM, respectively. In addition, neurotrophic assay in PC-12 cells showed that (+)-ganodermasine E, (-)-ganodermasine E, and ganodermasine I could stimulate neurite outgrowth at 10 µM, while the other isolates are inactive. The present findings will lend a hand for further utilization of G. sinensis.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Ganoderma
/
Alcaloides
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2022
Tipo de documento:
Article