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Functional characterization of two variants of mitochondrial topoisomerase TOP1MT that impact regulation of the mitochondrial genome.
Al Khatib, Iman; Deng, Jingti; Symes, Andrew; Kerr, Marina; Zhang, Hongliang; Huang, Shar-Yin Naomi; Pommier, Yves; Khan, Aneal; Shutt, Timothy E.
Afiliação
  • Al Khatib I; Department of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Deng J; Department of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Symes A; Department of Geomatics Engineering, Schulich School of Engineering, University of Calgary, Calgary, Alberta, Canada.
  • Kerr M; Discovery DNA, Calgary, Alberta, Canada.
  • Zhang H; Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland, USA.
  • Huang SN; Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland, USA.
  • Pommier Y; Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland, USA.
  • Khan A; Discovery DNA, Calgary, Alberta, Canada; M.A.G.I.C. Clinic Ltd (Metabolics and Genetics in Calgary), Department of Pediatrics, Cumming School of Medicine, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada.
  • Shutt TE; Departments of Biochemistry & Molecular Biology and Medical Genetics, Cumming School of Medicine, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. Electronic address: timothy.shutt@ucalgary.ca.
J Biol Chem ; 298(10): 102420, 2022 10.
Article em En | MEDLINE | ID: mdl-36030054
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiomiopatia Hipertrófica / DNA Topoisomerases Tipo I / Genoma Mitocondrial / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Humans / Newborn Idioma: En Revista: J Biol Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá País de publicação: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiomiopatia Hipertrófica / DNA Topoisomerases Tipo I / Genoma Mitocondrial / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Humans / Newborn Idioma: En Revista: J Biol Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá País de publicação: Estados Unidos