Intestinal epithelial organoids: regeneration and maintenance of the intestinal epithelium.
Curr Opin Genet Dev
; 76: 101977, 2022 10.
Article
em En
| MEDLINE
| ID: mdl-36058061
ABSTRACT
Vital functions of the intestines digestion, absorption, and surface barrier are performed by the intestinal epithelium, which consists of various differentiated cells and intestinal stem cells. Recent technological advances in sequencing technology, including single-cell transcriptomics and epigenetic analysis, have facilitated the genetic characterization of diverse intestinal epithelial cell types and surrounding mesenchymal niche environments. Organoids have allowed biological analysis of the human intestinal epithelium in coordination with genome engineering, genetic lineage tracing, and transplantation into orthotopic tissue. Together, these technologies have prompted the development of organoid-based regenerative therapies for intestinal diseases, including short-bowel syndrome. This article provides an overview of the current understanding of intestinal epithelial self-renewal during homeostasis and regeneration and provides a perspective for future organoid medicine.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Organoides
/
Intestinos
Limite:
Humans
Idioma:
En
Revista:
Curr Opin Genet Dev
Assunto da revista:
GENETICA
Ano de publicação:
2022
Tipo de documento:
Article