The collectin SP-A and its trimeric recombinant fragment protect alveolar epithelial cells from the cytotoxic and proinflammatory effects of human cathelicidin <i>in vitro</i>.

de Tapia, Lidia; García-Fojeda, Belén; Kronqvist, Nina; Johansson, Jan; Casals, Cristina

The collectin SP-A and its trimeric recombinant fragment protect alveolar epithelial cells from the cytotoxic and proinflammatory effects of human cathelicidin in vitro.

de Tapia, Lidia; García-Fojeda, Belén; Kronqvist, Nina; Johansson, Jan; Casals, Cristina.

Afiliação

de Tapia L; Department of Biochemistry and Molecular Biology, Complutense University of Madrid, Madrid, Spain.
García-Fojeda B; Department of Biochemistry and Molecular Biology, Complutense University of Madrid, Madrid, Spain.
Kronqvist N; Department of Biosciences and Nutrition, Neo, Karolinska Institutet, Huddinge, Sweden.
Johansson J; Department of Biosciences and Nutrition, Neo, Karolinska Institutet, Huddinge, Sweden.
Casals C; Department of Biochemistry and Molecular Biology, Complutense University of Madrid, Madrid, Spain.

Front Immunol ; 13: 994328, 2022.

Article em En | MEDLINE | ID: mdl-36105805

Assuntos

Células Epiteliais Alveolares; Colectinas; Células Epiteliais Alveolares/metabolismo; Antibacterianos; Peptídeos Catiônicos Antimicrobianos/metabolismo; Humanos; Pseudomonas aeruginosa/metabolismo; Catelicidinas

Palavras-chave

P2X7 channel; alveolar epithelial cells; antimicrobial activity; cathelicidin LL-37; collectin SP-A; cytotoxicity; inflammation; trimeric recombinant fragment

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colectinas / Células Epiteliais Alveolares Limite: Humans Idioma: En Revista: Front Immunol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Espanha País de publicação: Suíça

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