Functional cure of a chronic virus infection by shifting the virus - host equilibrium state.
Front Immunol
; 13: 904342, 2022.
Article
em En
| MEDLINE
| ID: mdl-36110838
ABSTRACT
The clinical handling of chronic virus infections remains a challenge. Here we describe recent progress in the understanding of virus - host interaction dynamics. Based on the systems biology concept of multi-stability and the prediction of multiplicative cooperativity between virus-specific cytotoxic T cells and neutralising antibodies, we argue for the requirements to engage multiple immune system components for functional cure strategies. Our arguments are derived from LCMV model system studies and are translated to HIV-1 infection.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Viroses
/
Infecções por HIV
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Front Immunol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Federação Russa
País de publicação:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND