Selection of the candidate compound at an early stage of new drug development: retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets.

Matsumoto, Shogo; Uehara, Shotaro; Kamimura, Hidetaka; Cho, Naoki; Ikeda, Hiroshi; Maeda, Satoshi; Kagiyama, Kensuke; Miyata, Atsunori; Suemizu, Hiroshi; Fukasawa, Kazumasa

Matsumoto, Shogo; Uehara, Shotaro; Kamimura, Hidetaka; Cho, Naoki; Ikeda, Hiroshi; Maeda, Satoshi; Kagiyama, Kensuke; Miyata, Atsunori; Suemizu, Hiroshi; Fukasawa, Kazumasa.

Afiliação

Matsumoto S; Drug and Discovery and Management Department, R and D Division, Meiji Seika Pharma Co., Ltd, Tokyo, Japan.
Uehara S; Department of Applied Research for Laboratory Animals, Central Institute for Experimental Animals, Kawasaki, Japan.
Kamimura H; Department of Applied Research for Laboratory Animals, Central Institute for Experimental Animals, Kawasaki, Japan.
Cho N; Business Promotion Department, CLEA Japan, Inc, Tokyo, Japan.
Ikeda H; Drug and Discovery and Management Department, R and D Division, Meiji Seika Pharma Co., Ltd, Tokyo, Japan.
Maeda S; Tokyo Animal and Diet Department, CLEA Japan, Inc, Tokyo, Japan.
Kagiyama K; Yaotsu Breeding Center, CLEA Japan, Inc, Gifu, Japan.
Miyata A; Yaotsu Breeding Center, CLEA Japan, Inc, Gifu, Japan.
Suemizu H; Drug and Discovery and Management Department, R and D Division, Meiji Seika Pharma Co., Ltd, Tokyo, Japan.
Fukasawa K; Department of Applied Research for Laboratory Animals, Central Institute for Experimental Animals, Kawasaki, Japan.

Xenobiotica ; 52(6): 613-624, 2022 Jun.

Article em En | MEDLINE | ID: mdl-36148579

Assuntos

Anti-Hipertensivos; Callithrix; Angiotensina II/metabolismo; Animais; Anti-Hipertensivos/metabolismo; Callithrix/metabolismo; Cães; Humanos; Macaca fascicularis/metabolismo; Preparações Farmacêuticas/metabolismo; Ratos; Estudos Retrospectivos; Valsartana/metabolismo

Palavras-chave

Allometry; MIST guidance; common marmoset; compound optimisation; metabolic profile; prediction; total clearance; volume of distribution

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Callithrix / Anti-Hipertensivos Tipo de estudo: Observational_studies Limite: Animals / Humans Idioma: En Revista: Xenobiotica Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão País de publicação: Reino Unido

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google