Totally Organic Hydrogel-Based Self-Closing Cuff Electrode for Vagus Nerve Stimulation.
Adv Healthc Mater
; 11(23): e2201627, 2022 12.
Article
em En
| MEDLINE
| ID: mdl-36148587
ABSTRACT
An intrinsically soft organic electrode consisting of poly(3,4-ethylenedioxythiophene)-modified polyurethane (PEDOT-PU) is embedded into a bilayer film of polyvinyl alcohol (PVA) hydrogels for developing a self-closing cuff electrode for neuromodulation. The curled form of the PVA hydrogel is prepared by releasing internal stress in the bilayer structure. The inner diameter of the cuff electrode is set to less than 2 mm for immobilization to the vagus nerve (VN) of humans and pigs. The stability of the immobilization is examined, while the pressure applied to a nerve bundle is at a harmless level (≈200 Pa). Since the electrode is totally organic, MRI measurements can be conducted without image artifacts. The large electric capacitance of the PEDOT-PU (≈27 mF cm-2 ) ensures a safe stimulation of living tissues without Faradaic reactions. The practical performance of the cuff electrode for VN stimulation is demonstrated by observation of bradycardia induction in a pig.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estimulação do Nervo Vago
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Adv Healthc Mater
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Japão