<i>IRF7</i>-deficient MDCK cell based on CRISPR/Cas9 technology for enhancing influenza virus replication and improving vaccine production.

Mayuramart, Oraphan; Poomipak, Witthaya; Rattanaburi, Somruthai; Khongnomnan, Kritsada; Anuntakarun, Songtham; Saengchoowong, Suthat; Chavalit, Tanit; Chantaravisoot, Naphat; Payungporn, Sunchai

IRF7-deficient MDCK cell based on CRISPR/Cas9 technology for enhancing influenza virus replication and improving vaccine production.

Mayuramart, Oraphan; Poomipak, Witthaya; Rattanaburi, Somruthai; Khongnomnan, Kritsada; Anuntakarun, Songtham; Saengchoowong, Suthat; Chavalit, Tanit; Chantaravisoot, Naphat; Payungporn, Sunchai.

Afiliação

Mayuramart O; Research Unit of Systems Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Poomipak W; Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Rattanaburi S; Research Unit of Systems Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Khongnomnan K; Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Anuntakarun S; Research Unit of Systems Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Saengchoowong S; Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Chavalit T; Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Chantaravisoot N; Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Payungporn S; Center of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

PeerJ ; 10: e13989, 2022.

Article em En | MEDLINE | ID: mdl-36164603

Assuntos

Vacinas contra Influenza; Influenza Humana; Interferon Tipo I; Orthomyxoviridae; Animais; Cães; Humanos; Vacinas contra Influenza/genética; Células Madin Darby de Rim Canino; Influenza Humana/genética; Fator VII/genética; Sistemas CRISPR-Cas/genética; Replicação Viral/genética; Interferon Tipo I/genética; Tecnologia

Palavras-chave

CRISPR-Cas9; IRF7; Influenza; Interferon; MDCK; Vaccine production

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Orthomyxoviridae / Vacinas contra Influenza / Interferon Tipo I / Influenza Humana Limite: Animals / Humans Idioma: En Revista: PeerJ Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Tailândia

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