Characterizing Actinotignum schaalii infections in a large Canadian healthcare region.

ABSTRACT

Aims: We characterize the epidemiology of Actinotignum schaalii within a large Canadian region after implementation of improved identification methods. Patients & methods: Positive cultures for A. schaalii from a centralized microbiology laboratory in Canada were analyzed. Clinical data were retrieved through administrative databases and chart reviews. Primary outcome was incidence of A. schaalii infections; secondary outcomes included mortality, hospital admission and length of stay. Results & conclusions: 86 unique isolates were studied, 37 bloodstream infections (BSI) and 49 non-BSIs. Patients with BSIs were older with more comorbidities, with urinary tract infections implicated as the most frequent source; skin abscesses caused the most non-BSIs. Hospitalization and 90-day mortality was higher in the BSI group. A. schaalii is an important community-acquired pathogen with the potential to cause invasive infections.

Actinotignum schaalii bacteria require special conditions and substances for their growth. Normally, A. schaalii reside in the urogenital tract without causing harm; however, they can be associated with urinary tract infections. Severe infections are increasingly identified with improved identification methods. This retrospective study included all positive cultures for A. schaalii from a centralized microbiology laboratory in Canada from 2012 to 2019. Eighty-six unique isolates were studied, including 37 bloodstream infections (BSIs) and 49 non-BSIs. The mean incidence rate of infections increased during the study. BSIs were seen in older men with other medical comorbidities and were associated with high hospitalization and mortality. Skin and soft-tissue infections comprised the majority of non-BSIs, occurring in younger patients and who had better clinical outcomes. Our population-based study of A. schaalii infections highlights the potential of this pathogen to cause severe infections.