Effects of yoga practice on physiological distress, fatigue and QOL in patients affected by breast cancer undergoing adjuvant radiotherapy.
Tech Innov Patient Support Radiat Oncol
; 24: 32-39, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-36176568
ABSTRACT
Background and purpose:
In this study we want to evaluate the efficacy of yoga practice on dysfunctional stress, inflammation and QOL in breast cancer patients undergoing adjuvant radiotherapy. Patients andmethods:
Patients with stage 0 to III breast cancer were recruited before starting radiotherapy (XRT) and were randomly assigned to yoga group (YG) two times a week during XRT or control group (CG). Self-report measures of QOL, fatigue and sleep quality, and blood samples were collected at day 1 of treatment, day 15, end of treatment and 1, 3 and 6 months later. Cortisol blood level, IL6, IL10, IL1RA, TNFα and lymphocyte-to-monocyte ratio were analyzed as measures of dysfunctional stress and inflammation.Results:
Patients started XRT and yoga classes in October 2019. Due to COVID-19 pandemic we closed the enrollment in March 2020. We analysed 24 patients, 12 YG and 12 CG. The analysis of blood cortisol levels revealed an interaction (p = 0.04) between yoga practice and time, in particular YG had lower cortisol levels at the end of XRT respect to CG (p-adj = 0.02). The analysis of IL-1RA revealed an interaction effect (p = 0.04) suggesting differences between groups at some time points that post-hoc tests were not able to detect.Conclusions:
To our knowledge, this is the first study to evaluate the effects of yoga in a cancer population studying inflammation markers, cortisol trend and QOL during and until 6 months after XRT. This study suggests that yoga practice is able to reduce stress and inflammation levels over time. Besides including a larger number of patients to increase the power, future studies should consider other inflammatory or pro inflammatory factors and long-term yoga program to gain more evidence on yoga practice benefits.
BFI, brief fatigue inventory; BH, Benjamini-Hochberg; BP, bodily pain; Breast cancer; CG, control group; EF, emotional functioning; GH, general health; LMR, lymphocyte-monocyte ratio; MCS, mental component scale; MH, mental health; Oncology; PCS, physical component scale; PF, physical functioning; PSQI, Pittsburgh sleep quality index; Physiological distress; QOL, quality of life; RE, role emotional; RP, role physical; Radiotherapy; SF, social functioning; VT, vitality; XRT, Radiotherapy; YG, yoga group; Yoga
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Aspecto:
Patient_preference
Idioma:
En
Revista:
Tech Innov Patient Support Radiat Oncol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Itália