Construction of a high-throughput aorta smooth muscle-on-a-chip for thoracic aortic aneurysm drug screening.

Zhu, Shichao; Abudupataer, Mieradilijiang; Yan, Shiqiang; Wang, Chunsheng; Wang, Li; Zhu, Kai

Zhu, Shichao; Abudupataer, Mieradilijiang; Yan, Shiqiang; Wang, Chunsheng; Wang, Li; Zhu, Kai.

Afiliação

Zhu S; Department of Cardiac Surgery and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Abudupataer M; Department of Cardiac Surgery and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yan S; Institutes of Biomedical Sciences and the Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Wang C; Department of Cardiac Surgery and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. Electronic address: wangchunsheng@fudan.edu.cn.
Wang L; Institutes of Biomedical Sciences and the Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College, Fudan University, Shanghai, 200032, China. Electronic address: wangljb@fudan.edu.cn.
Zhu K; Department of Cardiac Surgery and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. Electronic address: zhu.kai1@zs-hospital.sh.cn.

Biosens Bioelectron ; 218: 114747, 2022 Dec 15.

Article em En | MEDLINE | ID: mdl-36198238

Assuntos

Aneurisma da Aorta Torácica; Técnicas Biossensoriais; Humanos; Aneurisma da Aorta Torácica/tratamento farmacológico; Aneurisma da Aorta Torácica/genética; Aneurisma da Aorta Torácica/metabolismo; 2-Metoxiestradiol/metabolismo; Avaliação Pré-Clínica de Medicamentos; Dispositivos Lab-On-A-Chip; Aorta/metabolismo; Aorta/patologia; Digoxina; Dimetilpolisiloxanos; Fator 1 Induzível por Hipóxia/metabolismo; Músculo Liso/metabolismo; Músculo Liso/patologia

Palavras-chave

Drug screening; HIF-1alpha; High-throughput; Organ-on-a-chip; Thoracic aortic aneurysm

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Técnicas Biossensoriais / Aneurisma da Aorta Torácica Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans Idioma: En Revista: Biosens Bioelectron Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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