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A systematic review and meta-analysis of prophylactic medication of vestibular migraine.
Yiannakis, C; Hamilton, L; Slim, M; Kontorinis, G.
Afiliação
  • Yiannakis C; Department of Otolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK.
  • Hamilton L; Department of Otolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK.
  • Slim M; Department of Otolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK.
  • Kontorinis G; Department of Otolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK.
J Laryngol Otol ; 137(9): 953-961, 2023 Sep.
Article em En | MEDLINE | ID: mdl-36200521
OBJECTIVE: Vestibular migraine is in the process of recognition as an individual clinical entity. At present, no guidelines exist for its management. This study aimed to conduct a systematic review and meta-analysis to determine the effectiveness of available prophylactic medication. METHOD: A literature search was performed using PubMed, Ovid and Embase databases. Qualitative and quantitative analysis were performed as well as risk of bias analysis. Meta-analysis for the mean differences for pre- and post-treatment impact based on Dizziness Handicap Inventory and Vertigo Symptom Scale were performed. Proportionate transformation meta-analysis for the successful event rate based on complete symptoms control was explored. RESULTS: Thirteen publications were identified: 3 were randomised, controlled trials and 10 were non-randomised, controlled trials. Propranolol and venlafaxine improved the Vertigo Symptom Scale score by -13.31 points and -4.16 points, respectively, and the Dizziness Handicap Inventory score by -32.24 and -21.24, respectively. Only propranolol achieved statistically significant impact with 60 per cent of patients achieving complete symptom control. CONCLUSION: Propranolol should be offered as the first-line treatment for vestibular migraine followed by venlafaxine. Amitriptyline, flunarizine and cinnarizine showed a trend for symptom improvement, but this was not statistically significant.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tontura / Transtornos de Enxaqueca Tipo de estudo: Systematic_reviews Limite: Humans Idioma: En Revista: J Laryngol Otol Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tontura / Transtornos de Enxaqueca Tipo de estudo: Systematic_reviews Limite: Humans Idioma: En Revista: J Laryngol Otol Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de publicação: Reino Unido