Design, synthesis and pharmacological evaluation of 2-arylurea-1,3,5-triazine derivative (XIN-9): A novel potent dual PI3K/mTOR inhibitor for cancer therapy.

Sun, Xin; Zhang, Binliang; Luo, Leixuan; Yang, Yang; He, Bin; Zhang, Qian; Wang, Linxiao; Xu, Shan; Zheng, Pengwu; Zhu, Wufu

Sun, Xin; Zhang, Binliang; Luo, Leixuan; Yang, Yang; He, Bin; Zhang, Qian; Wang, Linxiao; Xu, Shan; Zheng, Pengwu; Zhu, Wufu.

Afiliação

Sun X; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China.
Zhang B; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China; School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510000, China.
Luo L; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China.
Yang Y; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China.
He B; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China.
Zhang Q; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China; School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510000, China.
Wang L; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China.
Xu S; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China. Electronic address: shanxu9891@126.com.
Zheng P; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China. Electronic address: zhengpw@126.com.
Zhu W; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang, Jiangxi 330013, China. Electronic address: zhuwufu-1122@163.com.

Bioorg Chem ; 129: 106157, 2022 Dec.

Article em En | MEDLINE | ID: mdl-36209563

Assuntos

Antineoplásicos; Neoplasias; Humanos; Fosfatidilinositol 3-Quinases/metabolismo; Inibidores de MTOR; Proteínas Proto-Oncogênicas c-akt/metabolismo; Simulação de Acoplamento Molecular; Transdução de Sinais; Serina-Treonina Quinases TOR/metabolismo; Inibidores de Fosfoinositídeo-3 Quinase/farmacologia; Proliferação de Células; Antineoplásicos/química; Triazinas/farmacologia; Linhagem Celular Tumoral; Inibidores de Proteínas Quinases/farmacologia; Neoplasias/tratamento farmacológico

Palavras-chave

2-arylurea-1,3,5-triazine; Cytotoxicity; Inhibitor; PI3K/mTOR; Structure-activity relationship

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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