Bromodomain Interactions with Acetylated Histone 4 Peptides in the BRD4 Tandem Domain: Effects on Domain Dynamics and Internal Flexibility.

Wernersson, Sven; Bobby, Romel; Flavell, Liz; Milbradt, Alexander G; Holdgate, Geoffrey A; Embrey, Kevin J; Akke, Mikael

Wernersson, Sven; Bobby, Romel; Flavell, Liz; Milbradt, Alexander G; Holdgate, Geoffrey A; Embrey, Kevin J; Akke, Mikael.

Afiliação

Wernersson S; Biophysical Chemistry, Center for Molecular Protein Science, Department of Chemistry, Lund University, SE-221 00Lund, Sweden.
Bobby R; Mechanistic and Structural Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, CambridgeCB4 0WG, U.K.
Flavell L; Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge Science Park, CambridgeCB4 0WG, U.K.
Milbradt AG; Mechanistic and Structural Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, CambridgeCB4 0WG, U.K.
Holdgate GA; Mechanistic and Structural Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, CambridgeCB4 0WG, U.K.
Embrey KJ; Mechanistic and Structural Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, CambridgeCB4 0WG, U.K.
Akke M; Biophysical Chemistry, Center for Molecular Protein Science, Department of Chemistry, Lund University, SE-221 00Lund, Sweden.

Biochemistry ; 61(21): 2303-2318, 2022 11 01.

Article em En | MEDLINE | ID: mdl-36215732

Assuntos

Histonas; Proteínas Nucleares; Histonas/metabolismo; Proteínas Nucleares/metabolismo; Fatores de Transcrição/química; Sítios de Ligação; Peptídeos/metabolismo; Proteínas de Ciclo Celular/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Histonas Idioma: En Revista: Biochemistry Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Suécia País de publicação: Estados Unidos

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