Effectiveness of maternal pertussis vaccination in Singapore: A test-negative case-control study.
Vaccine
; 40(46): 6570-6574, 2022 11 02.
Article
em En
| MEDLINE
| ID: mdl-36216649
ABSTRACT
Pertussis vaccination (Tdap -Tetanus-diphtheria-acellular pertussis) for pregnant women has been recommended since November 2017 in Singapore. In this prospective test-negative case-control study from 2018 to 2019, we aimed to evaluate vaccine effectiveness (VE) against pertussis infection and pertussis-related intensive care unit (ICU) admission according to Tdap (Tetanus-diphtheria-acellular pertussis) during pregnancy and/or infant pertussis vaccination. A total of 58 children (26 cases, 32 controls) were recruited with 4 ICU admissions. The median age was 3 months (interquartile range [IQR] 1.50-4.56 months). Overall, 25.9 % of mothers had received antenatal Tdap vaccination and 43.1 % of infants received pertussis vaccination, majority only 1 dose. Tdap in pregnancy alone without infant vaccine or with 0-1 infant dose had a VE of 97.62 % (95 % confidence interval [CI] 53.25-99.88 %), 98.17 % (95 %CI 66.61-99.9 %) respectively, against pertussis infection and 71.9 % (95 %CI 0.0-98.64), 75.86 % (95 % CI 0.0-98.78) respectively, against ICU admissions. Conclusion:
Maternal Tdap vaccination was highly protective against infant pertussis and should be routinely recommended for all pregnant women.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tétano
/
Coqueluche
/
Vacinas contra Difteria, Tétano e Coqueluche Acelular
/
Difteria
Tipo de estudo:
Observational_studies
Limite:
Child
/
Female
/
Humans
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Infant
/
Pregnancy
País/Região como assunto:
Asia
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Singapura