Stereodivergent Synthesis of (Z)-/(E)-ß-Sulfonylacrylamides via Tandem Difunctionalization of Alkynes with Sulfinates and Isocyanides.
Org Lett
; 24(41): 7632-7636, 2022 Oct 21.
Article
em En
| MEDLINE
| ID: mdl-36222482
ABSTRACT
Stereoselective difunctionalizations of the terminal and internal alkynes with various sulfinates and isocyanides have been achieved to prepare (Z)-/(E)-ß-sulfonylacrylamides. The (Z)-ß-sulfonylacrylamides were generated via a one-pot process that involves the reaction of terminal alkynes with sulfinates and isocyanides in the presence of iodine in sequential manner. The (E)-ß-sulfonylacrylamides were prepared in a two-step synthesis via palladium(II)-catalyzed addition of isocyanide to (E)-ß-iodovinylsulfones synthesized from alkynes.
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MEDLINE
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Alcinos
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Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2022
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Article
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Índia