The combination of early identification, chemotherapy, and autologous stem cell transplantation obtained favorable outcomes in unilateral primary adrenal lymphoma: A case report.

PURPOSE: Primary adrenal lymphoma (PAL) is an extremely rare entity, there were few cases have been reported. We report a 52-year-old female with unilateral PAL. METHODS: Case report. RESULTS: A rapid biopsy resulted in the diagnosis of diffuse large B-cell lymphoma after excluding pheochromocytoma. R-CHOP combined with CNS prophylaxis and autologous stem cell transplant (ASCT) has produced an excellent outcome. CONCLUSIONS: Primary adrenal lymphoma (PAL) is a sporadic and highly invasive malignant disease. Symptoms are atypical, making it difficult to obtain an accurate early diagnosis. Adrenal incidentaloma is usually the first clinical manifestation. Some patients may have fever, night sweats, weight loss, and lumbar and abdominal pain. Adrenal insufficiency (AI) may occur in a subset of patients. The identification of other adrenal malignancies, especially catecholamine-secreting tumors, is particularly important for early diagnosis.