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Solid Lipid Nanoparticles of Curcumin Designed for Enhanced Bioavailability and Anticancer Efficiency.
Yeo, Sooho; Kim, Min Je; Shim, Young Key; Yoon, Il; Lee, Woo Kyoung.
Afiliação
  • Yeo S; Center for Nano Manufacturing and Department of Nanoscience and Engineering, Inje University, Gimhae 50834, South Korea.
  • Kim MJ; Center for Nano Manufacturing and Department of Nanoscience and Engineering, Inje University, Gimhae 50834, South Korea.
  • Shim YK; Center for Nano Manufacturing and Department of Nanoscience and Engineering, Inje University, Gimhae 50834, South Korea.
  • Yoon I; Center for Nano Manufacturing and Department of Nanoscience and Engineering, Inje University, Gimhae 50834, South Korea.
  • Lee WK; Center for Nano Manufacturing and Department of Nanoscience and Engineering, Inje University, Gimhae 50834, South Korea.
ACS Omega ; 7(40): 35875-35884, 2022 Oct 11.
Article em En | MEDLINE | ID: mdl-36249382
Curcumin (Cur) has anticancer properties but exhibits poor aqueous solubility, permeability, and photostability. In this study, we aimed to develop a solid lipid nanoparticle (SLN) system to enhance Cur bioavailability. The characteristics of Cur-loaded SLNs prepared by sonication were evaluated using UV-vis and Fourier transform infrared spectroscopy. The mean particle size of the stearic acid-based, lauric acid-based, and palmitic acid-based SLNs was 14.70-149.30, 502.83, and 469.53 nm, respectively. The chemical interactions between Cur and lipids involved hydrogen bonding and van der Waals forces. The formulations with high van der Waals forces might produce a neat arrangement between Cur and lipids, leading to a decrease in particle size. The Cur formulations showed enhanced cytotoxicity in HeLa, A549, and CT-26 cells compared with pure Cur. Additionally, the anticancer effect is dependent on particle size and the type of cell line. Therefore, Cur-loaded SLNs have the potential for use in anticancer therapy.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Omega Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Coréia do Sul País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Omega Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Coréia do Sul País de publicação: Estados Unidos