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Photoacoustic Tomography Appearance of Fat Necrosis: A First-in-Human Demonstration of Biochemical Signatures along with Histological Correlation.
Goh, Yonggeng; Balasundaram, Ghayathri; Tan, Hui Min; Putti, Thomas Choudary; Ng, Celene Wei Qi; Fang, Eric; Bi, Renzhe; Tang, Siau Wei; Buhari, Shaik Ahmad; Hartman, Mikael; Chan, Ching Wan; Lim, Yi Ting; Olivo, Malini; Quek, Swee Tian.
Afiliação
  • Goh Y; Department of Diagnostic Imaging, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
  • Balasundaram G; Translational Biophotonics Laboratory, Institute of Bioengineering & Bioimaging, Agency for Science, Technology & Research, 11 Biopolis Way, #02-02 Helios, Singapore 138667, Singapore.
  • Tan HM; Department of Pathology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
  • Putti TC; Department of Pathology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
  • Ng CWQ; Department of Breast Surgery, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
  • Fang E; Department of Diagnostic Imaging, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
  • Bi R; Translational Biophotonics Laboratory, Institute of Bioengineering & Bioimaging, Agency for Science, Technology & Research, 11 Biopolis Way, #02-02 Helios, Singapore 138667, Singapore.
  • Tang SW; Department of Breast Surgery, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
  • Buhari SA; Department of Breast Surgery, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
  • Hartman M; Department of Breast Surgery, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
  • Chan CW; Department of Breast Surgery, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
  • Lim YT; Department of Diagnostic Imaging, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
  • Olivo M; Translational Biophotonics Laboratory, Institute of Bioengineering & Bioimaging, Agency for Science, Technology & Research, 11 Biopolis Way, #02-02 Helios, Singapore 138667, Singapore.
  • Quek ST; Department of Diagnostic Imaging, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.
Diagnostics (Basel) ; 12(10)2022 Oct 11.
Article em En | MEDLINE | ID: mdl-36292144
A 50-year-old woman with no past medical history presented with a left anterior chest wall mass that was clinically soft, mobile, and non-tender. A targeted ultrasound (US) showed findings suggestive of a lipoma. However, focal "mass-like" nodules seen within the inferior portion suggested malignant transformation of a lipomatous lesion called for cross sectional imaging, such as MRI or invasive biopsy or excision for histological confirmation. A T1-weighted image demonstrated a large lipoma that has a central fat-containing region surrounded by an irregular hypointense rim in the inferior portion, confirming the benignity of the lipoma. An ultrasound-guided photoacoustic imaging (PA) of the excised specimen to derive the biochemical distribution demonstrated the "mass-like" hypoechoic regions on US as fat-containing, suggestive of benignity of lesion, rather than fat-replacing suggestive of malignancy. The case showed the potential of PA as an adjunct to US in improving the diagnostic confidence in lesion characterization.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Diagnostics (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Singapura País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Diagnostics (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Singapura País de publicação: Suíça