Antibiotics in development for multiresistant gram-negative bacilli.
Med Intensiva (Engl Ed)
; 46(11): 630-640, 2022 11.
Article
em En
| MEDLINE
| ID: mdl-36302707
ABSTRACT
The rapid increase in antibiotic(ATB) resistance among Gram-negative bacilli(BGN), especially in strains of Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii, with high resistance patterns (XDR), poses a huge threat to health systems worldwide. In the last decade, different ATBs have been developed against XDR, some of which combine a lactam ß along with a ß-lactamase inhibitor, while others use non-ß-lactam inhibitors. Most of them have adequate "in vitro" activity on several ß-lactamases of class A, C and D of Ambler. However, combinations such as Ceftazidime/avibactam, Ceftolozane/Tazobactam and Meropenem/vaborbactam have no activity against metallo-ß-lactamases(MßL). New combinations such as Aztreonan/AVI, Cefepime/Zidebactam, or new cephalosporins such as Cefiderocol, have efficacy against MßL enzymes. Although some of these combinations are already approved and in the commercialization phase, many of them have yet to define their place within the treatment of microorganisms with high resistance through clinical studies.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bactérias Gram-Negativas
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Antibacterianos
Idioma:
En
Revista:
Med Intensiva (Engl Ed)
Ano de publicação:
2022
Tipo de documento:
Article
País de publicação:
ES
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ESPANHA
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ESPAÑA
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SPAIN